In certain patients with breast cancer, they may be a candidate for a lumpectomy with oncoplastic reconstruction and intra-operative radiation therapy. In patients with smaller tumors and certain biologic characteristics radiation can be undertaken at the time of lumpectomy during the operation. This can have fewer deleterious effects on the breast tissue, skin, and the overall aesthetic result. Oncoplastic reconstruction of lumpectomy defects involves closing the lumpectomy defect to produce a more aesthetically pleasing result. The ability to complete two of possibly three modalities of breast cancer treatment in one procedure can be very helpful to the health, recovery, and overall psyche of the breast cancer patient.